Puay Leng Lee Selected Research

3-Phosphoinositide-Dependent Protein Kinases

10/2013

PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Puay Leng Lee Research Topics

Disease

9	Neoplasms (Cancer) 01/2021 - 05/2007
7	Breast Neoplasms (Breast Cancer) 11/2020 - 05/2007
4	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 06/2008
3	Triple Negative Breast Neoplasms 01/2022 - 10/2015
3	Hypoxia (Hypoxemia) 01/2022 - 01/2016
3	Carcinogenesis 01/2016 - 10/2013
2	Neoplasm Metastasis (Metastasis) 11/2015 - 10/2015
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2015
1	Leukemia 01/2015
1	Prostatic Neoplasms (Prostate Cancer) 07/2014

Drug/Important Bio-Agent (IBA)

5	Histones (Histone)IBA 01/2018 - 05/2007
3	3-deazaneplanocinIBA 01/2015 - 05/2007
2	ChromatinIBA 01/2022 - 05/2007
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2021 - 01/2015
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 11/2017
2	Polycomb Repressive Complex 2IBA 01/2016 - 05/2007
2	Paclitaxel (Taxol)FDA LinkGeneric 11/2015 - 10/2015
1	Tyrosine (L-Tyrosine)FDA Link 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Deubiquitinating EnzymesIBA 01/2021
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 11/2020
1	Histone DemethylasesIBA 11/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Phenobarbital (Luminal)FDA Link 01/2018
1	11- (2- pyrrolidin- 1- ylethoxy)- 14,19- dioxa- 5,7,26- triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8,10,12(27),16,21,23- decaeneIBA 11/2017
1	Phosphotransferases (Kinase)IBA 11/2017
1	Cell-Free Nucleic AcidsIBA 11/2017
1	Matrix Metalloproteinases (MMPs)IBA 01/2016
1	Hypoxia-Inducible Factor 1IBA 01/2016
1	Interleukin-1 Receptor-Associated KinasesIBA 10/2015
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2015
1	Histone Deacetylase InhibitorsIBA 01/2015
1	InterferonsIBA 07/2014
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2013
1	3-Phosphoinositide-Dependent Protein KinasesIBA 10/2013
1	Sirolimus (Rapamycin)FDA Link 11/2010
1	DNA (Deoxyribonucleic Acid)IBA 11/2010
1	beta CateninIBA 06/2008
1	AdenosylhomocysteinaseIBA 05/2007

Therapy/Procedure

5	Therapeutics 11/2020 - 05/2007
3	Drug Therapy (Chemotherapy) 01/2018 - 01/2015
1	Immunotherapy 01/2022